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Hanaa Safya, Amine Mellouk, Julie Legrand, Sylvain M Le Gall, Mohcine Benbijja, Colette Kanellopoulos, Jean M Kanellopoulos, Pierre Bobé

Variations in cellular responses of mouse T cells to ATP stimulation do not depend on P2X7 receptor expression levels but on their activation and differentiation stage, Frontiers in Immunology, 2018, 27 February.


Wacquier B, Romero Campos HE, González-Vélez V, Combettes L, Dupont G. Mitochondrial Ca2+ dynamics in cells and suspensions. FEBS J. 2017 Oct 21. doi: 10.1111/febs.14296. [Epub ahead of print]

Sun CH, Wacquier B, Aguilar DI, Carayol N, Denis K, Boucherie S, Valencia-Gallardo C, Simsek C, Erneux C, Lehman A, Enninga J, Arbibe L, Sansonetti P, Dupont G, Combettes L, Tran Van Nhieu G.The Shigella type III effector IpgD recodes Ca2+ signals during invasion of epithelial cells. EMBO J. 2017 Sep 1;36(17):2567-2580. doi: 10.15252/embj.201696272. Epub 2017 Jul 12.

Merlen G, Ursic-Bedoya J, Jourdainne V, Kahale N, Glenisson M, Doignon I, Rainteau D, Tordjmann T. Bile acids and their receptors during liver regeneration: « Dangerous protectors ». Mol Aspects Med. 2017 Aug;56:25-33

Bartlett PJ, Antony AN, Agarwal A, Hilly M, Prince VL, Combettes L, Hoek JB, Gaspers LD. Chronic alcohol feeding potentiates hormone-induced calcium signalling in hepatocytes. J Physiol. 2017 May 15;595(10):3143-3164. doi: 10.1113/JP273891. Epub 2017 Apr 18.

Murtaza B, Berrichi M, Bennamar C, Tordjmann T, Djeziri FZ, Hichami A, Leemput J, Belarbi M, Ozdener H, Khan NA. Zizyphin modulates calcium signalling in human taste bud cells and fat taste perception in the mouse. Fundam Clin Pharmacol. 2017 Oct;31(5):486-494.

Dahan J, Levillayer F, Xia T, Nouët Y, Werts C, Fanton d’Andon M, Adib-Conquy M, Cassard-Doulcier AM, Khanna V, Chen J, Tordjmann T, Buendia MA, Jouvion G, Wei Y. LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor β1 Expression. Mol Cell Biol. 2017 May 2;37(10). pii: e00636-16

Gonzales E, Taylor SA, Davit-Spraul A, Thébaut A, Thomassin N, Guettier C, Whitington PF, Jacquemin E. MYO5B mutations cause cholestasis with normal serum gamma-glutamyl transferase activity in children without microvillous inclusion disease. Hepatology. 2017 Jan;65(1):164-173.


Wacquier B, Combettes L, Van Nhieu GT, Dupont G. Interplay Between Intracellular Ca(2+) Oscillations and Ca(2+)-stimulated Mitochondrial Metabolism. Sci Rep. 2016 Jan 18;6:19316. doi: 10.1038/srep19316.

Hilário-Souza E, Cuillel M, Mintz E, Charbonnier P, Vieyra A, Cassio D, Lowe J. 2016. Modulation of hepatic copper-ATPase activity by insulin and glucagon involves protein kinase A (PKA) signaling pathway. Biochim Biophys Acta. 2016 Nov;1862(11):2086-2097

Besnard A, Gautherot J, Julien B, Tebbi A, Garcin I, Doignon I, Péan N, Gonzales E, Cassio D, Grosse B, Liu B, Safya H, Cauchois F, Humbert L, Rainteau D, Tordjmann T. 2016. The P2X4 purinergic receptor impacts liver regeneration after partial hepatectomy in mice through the regulation of biliary homeostasis. Hepatology. 2016 Sep;64(3):941-53.

Nguyen D, Fayol O, Buisine N, Lecorre P, Uguen P. Functional Interaction between HEXIM and Hedgehog Signaling during Drosophila Wing Development. PLoS One. 2016 May 13;11(5):e0155438. doi: 10.1371/journal.pone.0155438. eCollection 2016

Dupont G, Combettes L. Fine tuning of cytosolic Ca (2+) oscillations. F1000Res. 2016 Aug 19;5. pii: F1000 Faculty Rev-2036. doi: 10.12688/f1000research.8438.1. eCollection


Gonzales E, Grosse B, Schuller B, Davit-Spraul A, Conti F, Guettier C, Cassio D, Jacquemin E. 2015. Targeted pharmacotherapy in progressive familial intrahepatic cholestasis type 2: Evidence for improvement of cholestasis with 4-phenylbutyrate .Hepatology. 2015 Aug;62(2):558-66

Funfak A, Fisch C, Abdel Motaal HT, Diener J, Combettes L, Baroud CN, Dupuis-Williams P. Paramecium swimming and ciliary beating patterns: a study on four RNA interference mutations.Integr Biol (Camb). 2015 Jan;7(1):90-100. doi: 10.1039/c4ib00181h.

Djillani A, Doignon I, Luyten T, Lamkhioued B, Gangloff SC, Parys JB, Nüße O, Chomienne C, Dellis O. Potentiation of the store-operated calcium entry (SOCE) induces phytohemagglutinin-activated Jurkat T cell apoptosis. Cell Calcium. 2015 Aug;58(2):171-85

Jourdainne V, Péan N, Doignon I, Humbert L, Rainteau D, Tordjmann T. The Bile Acid Receptor TGR5 and Liver Regeneration. Dig Dis. 2015;33(3):319-26

Gilgenkrantz H, Tordjmann T. Bile acids and FGF receptors: orchestrators of optimal liver regeneration. Gut. 2015 Sep;64(9):1351-2. doi: 10.1136/gutjnl-2014-308746.


Dianat N, Dubois-Pot-Schneider H, Steichen C, Desterke C, Leclerc P, Raveux A, Combettes L, Weber A, Corlu A, Dubart-Kupperschmitt A. Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells. Hepatology. 2014 Aug;60(2):700-14.

Wang T, Yanger K, Stanger BZ, Cassio D, Bi E. 2014. Cytokinesis defines a spatial landmark for hepatocyte polarization and apical lumen formation.  J Cell Sci. 2014 Jun 1;127(Pt 11):2483-92.

Cuillel M, Chevallet M, Charbonnier P, Fauquant C, Pignot-Paintrand I, Arnaud J, Cassio D, Michaud-Soret I, Mintz E. 2014. Interference of CuO nanoparticles with metal homeostasis in hepatocytes under sub-toxic conditions. Nanoscale. 2014;6(3):1707-15

Djillani A, Nüße O, Dellis O. Characterization of novel store-operated calcium entry effectors. Biochim Biophys Acta. 2014 Oct;1843(10):2341-7

Péan N, Doignon I, Tordjmann T. Gut microbiota and bile acids: an old story revisited (again). Clin Res Hepatol Gastroenterol. 2014 Apr;38(2):129-31



Karimian G, Buist-Homan M, Schmidt M, Tietge UJ, de Boer JF, Klappe K, Kok JW, Combettes L, Tordjmann T, Faber KN, Moshage H. Sphingosine kinase-1 inhibition protects primary rat hepatocytes against bile salt-induced apoptosis. Biochim Biophys Acta. 2013 Dec;1832(12):1922-9

Grosse B, Degrouard J, Jaillard D, Cassio D. 2013. Build them up and break them down: Tight junctions of cell lines expressing typical hepatocyte polarity with a varied repertoire of claudins. Tissue Barriers. 2013 Oct 1;1(4):

Boucherie S, Decaens C, Verbavatz JM, Grosse B, Erard M, Merola F, Cassio D, Combettes L. 2013. Cadmium disorganises the scaffolding of gap and tight junction proteins in the hepatic cell line WIF B9. Biol Cell. 2013 Dec;105(12):561-75.

Cassio D. Long term culture of MDCK strains alters chromosome content.  BMC Res Notes. 2013 Apr 24;6:162.

Dupré-Crochet, S, Erard,   M, Nüβe, O. 2013, ROS Production in Phagocytes: Why, When and Where? J. Leuk Biol. 94:657-670 (review)

Faure,   MC, Sulpice, J-C, Delattre, M, Lavielle, M, Prigent, M, Cuif, M-H, Melchior,   C, Tschirhart, E, Nüβe, O Dupré-Crochet, S. 2013, The recruitment of   p47phox and Rac2G12V at the phagosome is transient and   phosphatidylserine-dependent Biol Cell 105:1-18.

Péan N, Doignon I, Garcin I, Besnard A, Julien B, Liu B, Branchereau S, Spraul A, Guettier C, Humbert L, Schoonjans K, Rainteau D, Tordjmann T. The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice. Hepatology. 2013 May 17. doi: 10.1002/hep.26463.

BRIOUDE F, BOULIGAND J, FRANCOU B, FAGART J, ROUSSEL R, VIENGCHAREUN S, COMBETTES L, BRAILLY-TABARD S, LOMBÈS M, YOUNG J, GUIOCHON-MANTEL A. Two families with normosmic congenital hypogonadotropic hypogonadism and biallelic mutations in KISS1R (KISS1 Receptor): clinical evaluation and molecular characterization of a novel mutation.PLoS One. 2013;8(1):e53896. doi: 10.1371/journal.pone.0053896. Epub 2013 Jan 18.

TRAN VAN NHIEU G, LIU B.K, ZHENG J, PIERRE F, PRIGENT S, SANSONETTI P, ERNEUX C, JUNG KUK K, PANN-GHILL S, DUPONT G, COMBETTES L.Actin-based confinement of calcium responses during Shigella invasion.(Nature Commun. 2013 Mar 5;4:1567. doi: 10.1038/ncomms2561.)

Interaction between gambogic acid and dihydrofolate reductase and synergistic lethal effects with methotrexate on hepatoma cells. J. Deschatrette, K. Ng-Bonaventure, L. Philippe and C. Wolfrom. Anti-cancer Res. 33:133-142 (2013)


Lacoste C, Hervé J, Bou Nader M, Dos Santos A, Moniaux N, Valogne Y, Montjean R, Dorseuil O, Samuel D, Cassio D, Portulano C, Carrasco N, Bréchot C, Faivre J. 2012. Iodide transporter NIS regulates cancer cell motility and invasiveness by interacting with the Rho guanine nucleotide exchange factor LARG.Cancer Res. 2012 Nov 1;72(21):5505-15

Pujol AM, Cuillel M, Jullien AS, Lebrun C, Cassio D, Mintz E, Gateau C, Delangle P. 2012. A sulfur tripod glycoconjugate that releases a high-affinity copper chelator in hepatocytes. Angew Chem Int Ed Engl. 2012 Jul 23;51(30):7445-8.

Successful Gonzales E, Grosse B, Cassio D, Davit-Spraul A, Fabre M, Jacquemin E. 2012. mutation-specific chaperone therapy with 4-phenylbutyrate in a child with progressive familial intrahepatic cholestasis type 2. J Hepatol. 2012 Sep;57(3):695-8.

Blazquez AG, Briz O, Romero MR, Rosales R, Monte MJ, Vaquero J, Macias RI, Cassio D, Marin JJ. 2012. Characterization of the role of ABCG2 as a bile acid transporter in liver and placenta. Mol Pharmacol. 2012 Feb;81(2):273-83.

Grosse B, Cassio D, Yousef N, Bernardo C, Jacquemin E, Gonzales E. 2012. Claudin-1 involved in neonatal ichthyosis sclerosing cholangitis syndrome regulates hepatic paracellular permeability. Hepatology. 2012 Apr;55(4):1249-59

Nguyen D, Krueger BJ, Sedore SC, Brogie JE, Rogers JT, Rajendra TK, Saunders A, Matera AG, Lis JT, Uguen P, Price DH. The Drosophila 7SK snRNP and the essential role of dHEXIM in development.Nucleic Acids Res. 2012 Jul;40(12):5283-97.

Gonzales E, Grosse B, Cassio D, Davit-Spraul A, Fabre M, Jacquemin E. Successful mutation-specific chaperone therapy with 4-phenylbutyrate in a child with progressive familial intrahepatic cholestasis type 2. J Hepatol. 2012 May 16.

Fausther M, Gonzales E, Dranoff JA. Role of purinergic P2X receptors in the control of liver homeostasis. Wiley Interdiscip Rev Membr Transp Signal. 2012 May;1(3):341-348. Epub 2012 Jan 11.

Mauger, J.P. 2012. Role of the nuclear envelope in calcium signalling. Biol Cell. 104:70-83.

Tlili, A., M. Erard, M.C. Faure, X. Baudin, T. Piolot, S. Dupre-Crochet, and O. Nusse. 2012. Stable accumulation of p67phox at the phagosomal membrane and ROS production within the phagosome. J Leukoc Biol. 91:83-95.


Pujol AM, Cuillel M, Renaudet O, Lebrun C, Charbonnier P, Cassio D, Gateau C, Dumy P, Mintz E, Delangle P. 2011. Hepatocyte targeting and intracellular copper chelation by a thiol-containing glycocyclopeptide.

J Am Chem Soc. 2011 Jan 19;133(2):286-96

Nüsse, O. 2011, Biochemisty of the phagosome – the challenge to study a transient organelle The Scientific World Journal.11:2364-81. (review)

Abou-Lovergne, A., M. Collado-Hilly, F.P. Monnet, O. Koukoui, S. Prigent, J.F. Coquil, G. Dupont, and L. Combettes. 2011. Investigation of the role of sigma1-receptors in inositol 1,4,5-trisphosphate dependent calcium signaling in hepatocytes. Cell Calcium. 50:62-72.

 Combettes, L., and G. Dupont. 2011. [Experimental and computational approach of calcium signaling]. Med Sci (Paris). 27:170-6.

Dellis, O., A. Arbabian, B. Papp, M. Rowe, I. Joab, and C. Chomienne. 2011. Epstein-Barr Virus Latent Membrane Protein 1 Increases Calcium Influx through Store-operated Channels in B Lymphoid Cells. J Biol Chem. 286:18583-92.

Dellis, O., P. Mercier, and C. Chomienne. 2011. The boron-oxygen core of borinate esters is responsible for the store-operated calcium entry potentiation ability. BMC Pharmacol. 11:1.

Doignon, I., B. Julien, V. Serriere-Lanneau, I. Garcin, G. Alonso, A. Nicou, F. Monnet, M. Gigou, L. Humbert, D. Rainteau, D. Azoulay, D. Castaing, M.C. Gillon, D. Samuel, J.C. Duclos-Vallee, and T. Tordjmann. 2011. Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis. J Hepatol. 54:481-8.

Dupont, G., L. Combettes, G.S. Bird, and J.W. Putney. 2011. Calcium oscillations. Cold Spring Harb Perspect Biol. 3.

Grosse B, Cassio D, Yousef N, Bernardo C, Jacquemin E, Gonzales E. 2011. Claudin-1 involved in neonatal ichthyosis – sclerosing cholangitis syndrome, regulates hepatic paracellular permeability. Hepatology. 2011 Oct 26. doi: 10.1002/hep.24761. [Epub ahead of print] PMID: 22030598 [PubMed – as supplied by publisher]

Hamel, A., C. Fisch, L. Combettes, P. Dupuis-Williams, and C.N. Baroud. 2011. From the Cover: Transitions between three swimming gaits in Paramecium escape. Proc Natl Acad Sci U S A. 108:7290-5.

Prigent, M., E. Boy-Marcotte, L. Chesneau, K. Gibson, S. Dupre-Crochet, H. Tisserand, J.M. Verbavatz, and M.H. Cuif. 2011. The RabGAP proteins Gyp5p and Gyl1p recruit the BAR domain protein Rvs167p for polarized exocytosis. Traffic. 12:1084-97.

Tlili, A., S. Dupre-Crochet, M. Erard, and O. Nusse. 2011. Kinetic analysis of phagosomal production of reactive oxygen species. Free Radic Biol Med. 50:438-47.

Tordjmann, T. 2011. Hippo signalling: Liver size regulation and beyond. Clin Res Hepatol Gastroenterol. 35:344-6.


Lalioti V, Sandoval I, Cassio D, Duclos-Vallée JC. 2010. Molecular pathology of Wilson’s disease: a brief.J Hepatol. 2010 Dec;53(6):1151-3.

Bourge, M., A. Tlili, S. Dupre-Crochet, O. Nusse, and J.C. Sulpice. 2010. Amiloride derivatives modulate PS externalization in neutrophil-like PLB-985 cells. Biochem Pharmacol. 80:1012-20.

Collado-Hilly, M., H. Shirvani, D. Jaillard, and J.P. Mauger. 2010. Differential redistribution of Ca2+-handling proteins during polarisation of MDCK cells: Effects on Ca2+ signalling. Cell Calcium. 48:215-24.

Davit-Spraul, A., M. Fabre, S. Branchereau, C. Baussan, E. Gonzales, B. Stieger, O. Bernard, and E. Jacquemin. 2010. ATP8B1 and ABCB11 analysis in 62 children with normal gamma-glutamyl transferase progressive familial intrahepatic cholestasis (PFIC): phenotypic differences between PFIC1 and PFIC2 and natural history. Hepatology. 51:1645-55.

Dupre-Crochet, S., C. Hogan, and Y. Fujita. 2010. [Interactions between normal and transformed epithelial cells]. Med Sci (Paris). 26:457-8.

Gonzales, E., and E. Jacquemin. 2010. Mutation specific drug therapy for progressive familial or benign recurrent intrahepatic cholestasis: a new tool in a near future? J Hepatol. 53:385-7.

Gonzales, E., B. Julien, V. Serriere-Lanneau, A. Nicou, I. Doignon, L. Lagoudakis, I. Garcin, D. Azoulay, J.C. Duclos-Vallee, D. Castaing, D. Samuel, A. Hernandez-Garcia, S.S. Awad, L. Combettes, S. Thevananther, and T. Tordjmann. 2010. ATP release after partial hepatectomy regulates liver regeneration in the rat. J Hepatol. 52:54-62.

Lagoudakis, L., I. Garcin, B. Julien, K. Nahum, D.A. Gomes, L. Combettes, M.H. Nathanson, and T. Tordjmann. 2010. Cytosolic calcium regulates liver regeneration in the rat. Hepatology. 52:602-11.

Laurent, M., J. Deschatrette, and C.M. Wolfrom. 2010. Unmasking chaotic attributes in time series of living cell populations. PLoS One. 5:e9346.

Teixeira-Clerc, F., M.P. Belot, S. Manin, V. Deveaux, T. Cadoudal, M.N. Chobert, A. Louvet, A. Zimmer, T. Tordjmann, A. Mallat, and S. Lotersztajn. 2010. Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration. Hepatology. 52:1046-59.

Neutropenia dynamics in a case of T-LGL lymphoproliferation illustrate rapid turnover of granulocyte progenitors.Wolfrom CM, Lévy V, Deschatrette J. Cell Prolif. 2010 Jun;43(3):326-32. doi: 10.1111/j.1365-2184.2010.00678.x.



 Collado-Hilly, M., and J.F. Coquil. 2009. Ins(1,4,5)P3 receptor type 1 associates with AKAP9 (AKAP450 variant) and protein kinase A type IIbeta in the Golgi apparatus in cerebellar granule cells. Biol Cell. 101:469-80.

Delaunay, J.L., A.M. Durand-Schneider, D. Delautier, A. Rada, J. Gautherot, E. Jacquemin, T. Ait-Slimane, and M. Maurice. 2009. A missense mutation in ABCB4 gene involved in progressive familial intrahepatic cholestasis type 3 leads to a folding defect that can be rescued by low temperature. Hepatology. 49:1218-27.

Dupont, G., and L. Combettes. 2009. What can we learn from the irregularity of Ca2+ oscillations? Chaos. 19:037112.

Gonzales, E., A. Davit-Spraul, C. Baussan, C. Buffet, M. Maurice, and E. Jacquemin. 2009. Liver diseases related to MDR3 (ABCB4) gene deficiency. Front Biosci. 14:4242-56.

Gonzales, E., M.F. Gerhardt, M. Fabre, K.D. Setchell, A. Davit-Spraul, I. Vincent, J.E. Heubi, O. Bernard, and E. Jacquemin. 2009. Oral cholic acid for hereditary defects of primary bile acid synthesis: a safe and effective long-term therapy. Gastroenterology. 137:1310-1320 e1-3.

Jacquemin, E., B. Hermeziu, Y. Kibleur, I. Friteau, D. Mathieu, F. Le Coz, D. Moyse, M. Gerardin, E. Jacqz-Aigrain, and A. Munck. 2009. Bioavailability of oral vitamin E formulations in adult volunteers and children with chronic cholestasis or cystic fibrosis. J Clin Pharm Ther. 34:515-22.



 Clair, C., L. Combettes, F. Pierre, P. Sansonetti, and G. Tran Van Nhieu. 2008. Extracellular-loop peptide antibodies reveal a predominant hemichannel organization of connexins in polarized intestinal cells. Exp Cell Res. 314:1250-65.

Decaens, C., M. Durand, B. Grosse, and D. Cassio. 2008. Which in vitro models could be best used to study hepatocyte polarity? Biol Cell. 100:387-98.

Dupont, G., A. Abou-Lovergne, and L. Combettes. 2008. Stochastic aspects of oscillatory Ca2+ dynamics in hepatocytes. Biophys J. 95:2193-202.

Girard, M., E. Jacquemin, A. Munnich, S. Lyonnet, and A. Henrion-Caude. 2008. miR-122, a paradigm for the role of microRNAs in the liver. J Hepatol. 48:648-56.

Hernandez, S., Y. Tsuchiya, J.P. Garcia-Ruiz, V. Lalioti, S. Nielsen, D. Cassio, and I.V. Sandoval. 2008. ATP7B copper-regulated traffic and association with the tight junctions: copper excretion into the bile. Gastroenterology. 134:1215-23.

Serriere, V., D. Tran, N. Stelly, M. Claret, G. Alonso, T. Tordjmann, and G. Guillon. 2008. Vasopressin-induced morphological changes in polarized rat hepatocyte multiplets: dual calcium-dependent effects. Cell Calcium. 43:95-104.

Vigant, F., D. Descamps, B. Jullienne, S. Esselin, E. Connault, P. Opolon, T. Tordjmann, E. Vigne, M. Perricaudet, and K. Benihoud. 2008. Substitution of hexon hypervariable region 5 of adenovirus serotype 5 abrogates blood factor binding and limits gene transfer to liver. Mol Ther. 16:1474-80.